Research Article

Identification of the Genetic Mutations Associated With INH Mono Resistance in Mycobacterium Tuberculosis Isolates From Patients in a Tertiary Care Centre

  • Dr Varnana Suresh AT
    Senior Resident,
  • Dr.Akshada M Vernekar
    Senior Resident,
  • Dr. Uday C. Kakodkar
    Professor and Head of the Department,
  • Dr. Sanjivani Keny
    Associate Professor Department of Respiratory Medicine, Goa Medical College, Taleigao – Goa
Published March 1, 2025 Issue Vol. 16 No. 02 (2025) Section Medical Science Pages 20272-20275
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Abstract

Tuberculosis remains a significant public health issue worldwide, with India having one of the highest burden of disease. Isoniazid (INH) is a cornerstone drug in the treatment of TB. However, INH mono resistance poses a considerable challenge to effective TB control. Understanding genetic mutations responsible for INH resistance is crucial for the development of diagnostic tools and treatment strategies. Our study aims to identify and characterize the genetic mutations associated with INH mono resistance in Mycobacterium tuberculosis isolates from patients in Goa. Also, our study aims to evaluate whether patients developing isoniazid mono resistant tuberculosis occurs more in patients with anti-TB treatment in the past.

How to Cite

Dr Varnana Suresh AT, Dr.Akshada M Vernekar, Dr. Uday C. Kakodkar, Dr. Sanjivani Keny . (2025). Identification of the Genetic Mutations Associated With INH Mono Resistance in Mycobacterium Tuberculosis Isolates From Patients in a Tertiary Care Centre. International Journal of Contemporary Research and Review , Vol. 16 No. 02 (2025) , 20272-20275 .